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PHI-1
Description:
PHI-1
Trade Name:
Upstate (Millipore)
Qty/Pk:
50 µg
Key Applications:
Kinase Assay
Application Notes:
Highly specific inhibitor of type-1 Ser/Thr phosphatase (PP1).
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
UniProt Summary:
FUNCTION: SwissProt: P62140 # Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.
COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
SIZE: 327 amino acids; 37187 Da
SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity). Interacts with PPP1R7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: SwissProt: P62140 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
SIZE: 327 amino acids; 37187 Da
SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity). Interacts with PPP1R7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: SwissProt: P62140 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
Quality Assurance:
Routinely evaluated by inhibition of dephosphorylation of phosphorylase by PP-1
Brand Family:
Upstate
Presentation:
PBS
UniProt Number:
Storage Conditions:
2 years at -20°C
Inhibitor Type:
Kinase
Gene Symbol:
- PPP1CA
- PP-1A
- MGC15877
- MGC1674
- PPP1A
Protein or Enzyme Type:
Inhibitors
Product Name:
PHI-1
Entrez Gene Number: