Epoxomicin Inhibitor

Epoxomicin Inhibitor

Upstate (Millipore)

100 µg

Inhibits Activity/Function

Cell permeable, potent and specific irreversible inhibitor of the proteasome. Novel mechanism of action. Blocks chymotrypsin-like, trypsin like and PGPH activities of the proteasome. Regulates antigen presentation at non-toxic doses. Displays in vivo anti-inflammatory activity in mouse ear inflammation assay and in vitro NF-kB inhibition. The product is not sterile.

Mammals

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This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
SIZE: 76 amino acids; 8565 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).

Upstate

P62988

Store at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

• RPS27A
• CEP80
• ubiquitin
• ubiquitin-CEP80
• UBCEP1
• Ubiquitin.
• UBA52
• UBCEP2
• UBA80
• UBC
• UBB
• HUBCEP80

Ubiquitin & Related Enzymes

Epoxomicin Inhibitor

NM_002954.3