Ubiquitin Aldehyde Inhibitor

Ubiquitin Aldehyde Inhibitor

Upstate (Millipore)

50 µg

Inhibits Activity/Function

Purified bovine ubiquitin (Ub) synthetically modified to convert the C-terminal glycine carboxyl to an aldehyde. Potent and specific inhibitor of ubiquitin C-terminal hydrolases (UCHs). Recommended concentration for maximal inhibition is 2-5 µM. Soluble in DMSO and acetonitrile

Mammals

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This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
SIZE: 76 amino acids; 8565 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).

491.44

Upstate

P62988

Store at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

• RPS27A
• CEP80
• ubiquitin
• ubiquitin-CEP80
• UBCEP1
• Ubiquitin.
• UBA52
• UBCEP2
• UBA80
• UBC
• UBB
• HUBCEP80

Ubiquitin & Related Enzymes

Ubiquitin Aldehyde Inhibitor

NM_002954.3