Ordering Information
- : 328007-1MG
- : 1 MG
Product Images
ERK Inhibitor II, FR180204 | CAS 865362-74-9 | Calbiochem | 1MG
Description:
ERK Inhibitor II, FR180204 | CAS 865362-74-9 | Calbiochem | 1MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
1 MG
Background Information:
A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 = 3.1 µM). ERK Inhibitor II, Negative Control is also available (Cat. No. 328008).
Applications:
The ERK Inhibitor II, FR180204, also referenced under CAS 865362-74-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
327.3
CAS No.:
865362-74-9
Brand Family:
Calbiochem
Presentation:
Yellow solid. Packaged under inert gas.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at +2 - 8°C.
Properties:
Solubility: DMSO (10 mg/ml).
Gene Symbol:
MAPK1, MAPK2
PubChem ID:
26758672
Product Name:
ERK Inhibitor II, FR180204 | CAS 865362-74-9 | Calbiochem | 1MG
Entrez Gene Number:
Empirical Formula:
C18H13N7
Alternate Names:
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine