Información pedidos
Imágenes del producto
WB: ATF2 (lane 1) and ATF2 phosphorylated by JNK1α1/SAPK1c, active (lane 2) were probed with anti-phospho-ATF2 (Thr69) (2.0μg/ml)
Anti-phospho-ATF2 (Thr69)
| Reactividad de especies | Aplicaciones claves | Huésped | Formato | Tipo de anticuerpo |
|---|---|---|---|---|
| H | KA | Sheep | Purified | Polyclonal Antibody |
Número UniProt:
UniProt Summary
FUNCTION: SwissProt: P15336 # Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
SIZE: 487 amino acids; 52277 Da
SUBUNIT: Binds DNA as a dimer and can form a ... ver más »
SIZE: 487 amino acids; 52277 Da
SUBUNIT: Binds DNA as a dimer and can form a ... ver más »
Número GenBank:
Entrez Gene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by dir
...
ver más »
Description:
Anti-phospho-ATF2 (Thr69)
Specificity:
ATF2 phosphorylated on Threonine 69.
Key Applications:
Kinase Assay
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with mouse and rat, based on sequence homology
Isotype:
IgG
Immunogen:
Synthetic peptide corresponding to amino acids surrounding phosphorylated Thr69 of human ATF2.
Modifications:
Phosphorylation
Molecular Weight:
37kDa
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
Gene Symbol:
- ATF2
- CRE-BP1
- MGC111558
- HB16
- CREBP1
- CREB2
- TREB7
Quality Assurance:
Routinely evaluated by immunoblot on recombinant ATF2 (12-367), phosphorylated by JNK1/SAPK1c, active (14-327) using a cold kinase assay.
Antibody Category:
Epigenetics & Nuclear Function
Antibody Sub-Category:
Transcription Factors
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Upstate (Millipore)
Antibody Type:
Polyclonal Antibody
Format:
Purified
Host:
Sheep
Purification Method:
protein G purified