Ordering Information
- : 420119-25MG
- : 25 MG
Product Images
JNK Inhibitor II | CAS 129-56-6 | Calbiochem | 25MG
Description:
JNK Inhibitor II | CAS 129-56-6 | Calbiochem | 25MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
25 MG
Background Information:
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-ɣ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
Applications:
The JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
220.2
CAS No.:
129-56-6
Brand Family:
Calbiochem
Presentation:
Yellowish orange solid. Packaged under inert gas.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: DMSO (15 mg/ml). For every 10 µM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility.
Gene Symbol:
MAPK8, MAPK9, MAPK10
PubChem ID:
26758988
RTCS No.:
CB4585000
Product Name:
JNK Inhibitor II | CAS 129-56-6 | Calbiochem | 420119-25MG
Entrez Gene Number:
Empirical Formula:
C14H8N2O
Alternate Names:
- SAPK Inhibitor II
- 1,9-pyrazoloanthrone
- SP600125
- Anthra[1,9-cd]pyrazol-6(2H)-one