Ordering Information
- : 440202-25MG
- : 25 MG
Product Images
LY 294002 (LY294002) | CAS 154447-36-6 | Calbiochem | 25MG
Description:
LY 294002 (LY294002) | CAS 154447-36-6 | Calbiochem | 25MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
25 MG
Background Information:
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
307.4
CAS No.:
154447-36-6
Brand Family:
Calbiochem
Presentation:
Off-white solid.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: DMSO (20 mg/ml) or Ethanol. Slight warming may be required to achieve complete solubilization.
Gene Symbol:
PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG
PubChem ID:
26759070
Product Name:
LY 294002 (LY294002) | CAS 154447-36-6 | Calbiochem | 25MG
Entrez Gene Number:
Empirical Formula:
C19H17NO3
Alternate Names:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one