Content Loading...
Content Loading...
MILLIPLEX MAP Phospho p38/SAPK (Thr180/Tyr182) MAPmate
Description:
MILLIPLEX MAP Phospho p38/SAPK (Thr180/Tyr182) MAPmate
Trade Name:
MILLIPLEX
Qty/Pk:
1 kit
Key Applications:
Multiplexing
Application Notes:
The MILLIPLEX MAP Phospho p38/SAPK (Thr180/Tyr182) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated p38/SAPK (Thr180/Tyr182) in cell lysates using the Luminex® 100 IS, 200, or HTS system.
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
UniProt Summary:
FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
COFACTOR: Magnesium (By similarity).
SIZE: 364 amino acids; 41357 Da
TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
COFACTOR: Magnesium (By similarity).
SIZE: 364 amino acids; 41357 Da
TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
Configuration:
Single Plex
Components:
- Anti-p38 Beads
- Anti-phospho-p38 (Thr180/Tyr182), Biotin
Brand Family:
Upstate
UniProt Number:
Panel Type:
Cell Signaling
Detection Methods:
- Fluorescent
- Luminex xMAP
Packaging:
100 assay points
Modifications:
Phosphorylation
Gene Symbol:
- MAPK11
- p38-2
- p38b
- SAPK2B
- SAPK2
- PRKM11
- P38BETA2
- P38B
- p38Beta
- p38beta2
Array Type:
Antibody Arrays
Product Name:
MILLIPLEX MAP Phospho p38/SAPK (Thr180/Tyr182) MAPmate
Entrez Gene Number:
Analytes Available:
p38, p38/SAPK2A/B (Thr180/Tyr182)