Phospho-c-Jun (Ser73) Beadmates™
Description:
Phospho-c-Jun (Ser73) Beadmates™
Trade Name:
MILLIPLEX
Key Applications:
Multiplexing
Application Notes:
Optimal antibody pair for the detection of Phospho-c-Jun (Ser73) using the Beadlyte® Cell Signaling Buffer Kit (Catalogue No. 48-600) and the Luminex® Instrument System (Catalogue No. 40-010) .
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Jun is a component of the transcription factor AP-1, and can constitute AP-1 activity either as a homodimer or as a heterodimer with Fos. By contrast with Fos, Jun is expressed constitutively, and can be activated by phosphorylation of serines 63 and/or 73. These sites are targets for the SAPK1/JNK family of protein kinases, and their phosphorylation states can be monitored using antibodies specific for the phospho-epitopes. In addition, Jun is phosphorylated by GSK3 on sites which inhibit Jun activity. Since GSK3 is inactivated by Akt, the Akt pathway results in Jun activation.
Therapeutic Areas:
Oncology
Modifications:
Phosphorylation
Components:
- Beadlyte™ Anti-Jun Beads
- Beadlyte™ Anti-Phospho-Jun (Ser73), Biotin
Kit Type:
- Cancer Kits
- Cell Signaling Kits
Gene Symbol:
- JUN
- AP1
- p39
- c-Jun
Analytes Available:
c-Jun
Detection Methods:
Luminex xMAP
Kit or Assay Type:
- Cancer Kits
- Cell Signaling Kits
- Multiplex Assays
Assay Type:
Multiplex Assays