Ordering Information

Catalogue Number : 46-622
Qty/Pk : 1 kit

Product Family Information

	MILLIPLEX MAP – Human Cell Signaling Portfolio The cell’s ability to respond to its environment is essential for normal development, cellular repair and immunity and is the basis of homeostasis. Errors in these pathways, caused by mutations that may result in constitutive expression or total inhibition of protein transcription, are responsible for such diseases as diabetes, autoimmune disorders and cancer. » More…

MILLIPLEX MAP Phospho c-Jun (Ser73) MAPmate - Cell Signaling Single Plex or Multiplex Assay

Description:

MILLIPLEX MAP Phospho c-Jun (Ser73) MAPmate

Trade Name:

MILLIPLEX

Qty/Pk:

1 kit

Applications:

This MILLIPLEX® MAP Phospho c-Jun (Ser73) MAPmate is a Cell Signaling single plex or multiplex assay. The analyte available for this kit is c-Jun (Ser73).

Key Applications:

Multiplexing

Application Notes:

The MILLIPLEX MAP Phospho c-Jun (Ser 73) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated c-Jun (Ser 73) in cell lysates using the Luminex® 100 IS, 200, or HTS system.

Species Reactivity:

Human

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Entrez Gene Summary:

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

UniProt Summary:

FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.

Brand Family:

Upstate

Modifications:

Phosphorylation

Gene Symbol: