Ordering Information

Catalogue Number : 46-633
Qty/Pk : 1 kit

Product Family Information

	MILLIPLEX MAP – Human Cell Signaling Portfolio The cell’s ability to respond to its environment is essential for normal development, cellular repair and immunity and is the basis of homeostasis. Errors in these pathways, caused by mutations that may result in constitutive expression or total inhibition of protein transcription, are responsible for such diseases as diabetes, autoimmune disorders and cancer. » More…

MILLIPLEX MAP Phospho STAT6 (Tyr641) MAPmate

Description:

Trade Name:

MILLIPLEX

Qty/Pk:

1 kit

Key Applications:

Multiplexing

Application Notes:

The MILLIPLEX MAP Phospho STAT6 (Tyr641) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated STAT6 (Tyr641) in cell lysates using the Luminex® 100 IS, 200, or HTS system.

Species Reactivity:

Human

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Entrez Gene Summary:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

UniProt Summary:

FUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
SIZE: 847 amino acids; 94135 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.

Configuration:

Single Plex

Components: