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  • : 46-635
  • : 1 kit
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MILLIPLEX MAP Phospho STAT2 (Tyr690) MAPmate - Cell Signaling Single Plex or Multiplex Assay

Description:
MILLIPLEX MAP Phospho STAT2 (Tyr690) MAPmate
Trade Name:
MILLIPLEX
Qty/Pk:
1 kit
Applications:
This MILLIPLEX® MAP Phospho STAT2 (Tyr690) MAPmate is a Cell Signaling single plex or multiplex assay. The analyte available for this kit is STAT2 (Tyr690).
Key Applications:
Multiplexing
Application Notes:
The MILLIPLEX MAP Phospho STAT2 (Tyr690) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated STAT2 (Tyr690) in cell lysates using the Luminex® 100™ IS, 200™, or HTS system.
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus
UniProt Summary:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Storage Conditions:
Recommended storage for kit components is 2 - 8°C
Product Name:
MILLIPLEX MAP Phospho STAT2 (Tyr690) MAPmate
Analytes Available:
IκBα, STAT2 (Tyr690)
Configuration:
Single Plex
Components:
  • MILLIPLEX MAP Anti-phospho STAT2 (Tyr690) Beads
  • MILLIPLEX MAP Anti-phospho STAT2 (Tyr690), biotin
  • MILLIPLEX MAP HeLa Cell Lysate: IFNa Stimulated
UniProt Number:
P52630
Panel Type:
Cell Signaling
Detection Methods:
  • Luminex xMAP
  • Fluorescent
Entrez Gene Number:
NM_005419