Ordering Information

Catalogue Number : 46-658
Qty/Pk : 1 kit

Product Family Information

	MILLIPLEX MAP – Human Cell Signaling Portfolio The cell’s ability to respond to its environment is essential for normal development, cellular repair and immunity and is the basis of homeostasis. Errors in these pathways, caused by mutations that may result in constitutive expression or total inhibition of protein transcription, are responsible for such diseases as diabetes, autoimmune disorders and cancer. » More…

MILLIPLEX MAP Phospho ATF2 (Thr69/71) MAPmate

Description:

Trade Name:

MILLIPLEX

Qty/Pk:

1 kit

Key Applications:

Multiplexing

Application Notes:

The MILLIPLEX MAP Phospho ATF2 (Thr69/71) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated ATF2 (Thr69/71) in cell lysates using the Luminex® 100™ IS, 200™, or HTS system.

Species Reactivity:

Human

Usage Statement:

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Entrez Gene Summary:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.

UniProt Summary:

Function: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

Configuration:

Single Plex

Components:

Anti-phospho ATF2 (Thr69/71) Beads
Anti-phospho ATF2 (Thr69/71), biotin

Brand Family:

Upstate

UniProt Number:

P15336

Panel Type:

Cell Signaling

Detection Methods:

Luminex xMAP
Fluorescent

Packaging:

100 assay points

Modifications:

Phosphorylation

Product Name:

MILLIPLEX MAP Phospho ATF2 (Thr69/71) MAPmate

Entrez Gene Number:

NM_001880

Analytes Available:

ATF2 (Thr69/71), JNK

Ordering Information

Product Family Information

MILLIPLEX MAP – Human Cell Signaling Portfolio

MILLIPLEX MAP Phospho ATF2 (Thr69/71) MAPmate

Product Resources

MSDS

Protocols

Product Support