Ordering Information
- : 475837-5MG
- : 5 MG
Product Images
MIF Antagonist, ISO-1 | CAS 478336-92-4 | Calbiochem | 5MG
Description:
MIF Antagonist, ISO-1 | CAS 478336-92-4 | Calbiochem | 5MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
5 MG
Background Information:
A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
Applications:
The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF. This small molecule/inhibitor is primarily used for inflammation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
235.1
CAS No.:
478336-92-4
Brand Family:
Calbiochem
Presentation:
Light yellow solid. Packaged under inert gas.
UniProt Number:
Storage Conditions:
Shipped on Blue Ice or Dry Ice. Store at -20°C.
Properties:
Solubility: DMSO (10 mg/ml).
Gene Symbol:
MIF
PubChem ID:
26759171
Product Name:
MIF Antagonist, ISO-1 | CAS 478336-92-4 | Calbiochem | 5MG
Entrez Gene Number:
Empirical Formula:
C12H13NO4
Alternate Names:
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester