Ordering Information
- : 513000-25MG
- : 25 MG
Product Images
PD 98059 (PD98059) | CAS 167869-21-8 | Calbiochem | 25MG
Description:
PD 98059 (PD98059) | CAS 167869-21-8 | Calbiochem | 25MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
25 MG
Background Information:
Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
267.3
CAS No.:
167869-21-8
Brand Family:
Calbiochem
Presentation:
Pale yellow solid.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: DMSO (20 mg/ml) or Methanol (0.7 mg/ml).
Gene Symbol:
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7
PubChem ID:
26759319
Product Name:
PD 98059 (PD98059) | CAS 167869-21-8 | Calbiochem | 25MG
Entrez Gene Number:
Empirical Formula:
C16H13NO3
Alternate Names:
- 2′-Amino-3′-methoxyflavone
- MEK Inhibitor V