PTK/PI 3-K/mTOR Inhibitor, PP121 | CAS 1092788-83-4 | Calbiochem | 5 MG

PTK/PI 3-K/mTOR Inhibitor, PP121 | CAS 1092788-83-4 | Calbiochem | 5 MG

Calbiochem (EMD Millipore)

5 MG

A cell-permeable pyrazolopyrimidine compound that effectively targets the ATP pocket of both protein tyrosine kinases (IC₅₀ <0.26 µM against Abl, EGFR, EphB4, Hck, PDGFR, RET, Src, Src^T338I, and VEGFR2) and PI 3-K family kinases (IC₅₀ <1.4 µM against p110α/ β/ δ/ ɣ, mTOR, and DNA-PK). PP121 is less effective against ser/thr kinases and exhibits significant inhibition of only 14 ser/thr kinases (≥70% inhibition with 1 µM inhibitor and 10 µM ATP) in a 219 kinase panel screening. Individually targeting Ret by sorafenib (IC₅₀ = 780 nM) or PI 3-K/mTOR pathway by PI-103 (IC₅₀ = 800 nM, Cat. Nos. 528100 and 528101) is shown to be less effective than PP121 treatment (IC₅₀ = 50 nM) in inhibiting the proliferation of Ret C634W-expressing TT thyroid carcinoma cultures.

The PTK/PI 3-K/mTOR Inhibitor, PP121, also referenced under CAS 1092788-83-4, controls the biological activity of PTK/PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

319.4

1092788-83-4

Calbiochem

White solid. Packaged under inert gas.

Shipped at Ambient Temperature. Store at -20°C.

PTK/PI 3-K/mTOR Inhibitor, PP121 | CAS 1092788-83-4 | Calbiochem | 5 MG

C₁₇H₁₇N₇

• 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• PI 3-K Inhibitor XIII
• PI 3-K/mTOR Inhibitor II
• VEGFR Tyrosine Kinase Inhibitor XXXII
• VEGFR2 Kinase Inhibitor XXX
• mTOR Inhibitor VII