Ordering Information
- : 553210-10MG
- : 10 MG
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Rapamycin (mTOR Inhibitor) | CAS 53123-88-9 | Calbiochem | 10MG
Description:
Rapamycin (mTOR Inhibitor) | CAS 53123-88-9 | Calbiochem | 10MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
10 MG
Background Information:
Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
Applications:
Rapamycin, also referenced under CAS 53123-88-9, modulates the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
914.2
CAS No.:
53123-88-9
Brand Family:
Calbiochem
Presentation:
Clear film.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: DMSO (25 mg/ml) Ethanol (9 mg/ml), or Methanol (1 mg/ml).
Gene Symbol:
AKT1, AKT2, AKT3, MTOR, P110, PI3K p85, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R4, PIK3R5, PIK3R6
PubChem ID:
26759434
RTCS No.:
VE6250000
Product Name:
Rapamycin (mTOR Inhibitor) | CAS 53123-88-9 | Calbiochem | 10MG
Entrez Gene Number:
- NP_001014431.1
- NP_001014432.1
- NP_005154.2
- NP_001617.1
- NP_005456.1
- NP_859029.1
- NP_004949.1
- NP_002636.2
- NP_002637.3
- NP_004561.3
- NP_002638.2
- NP_006209.2
- NP_006210.1
- NP_005017.3NP_005017.3
- NP_002640.2
- NP_852556.2
- NP_852664.1
- NP_852665.1
- NP_005018.1
- NP_001107644.1
- NP_003620.3
- NP_055417.1
- NP_001136105.1
- NP_055123.2
- NP_001010855.1
Empirical Formula:
C51H79NO13
Alternate Names:
mTOR Inhibitor I