Ordering Information
- : 553502-10MG
- : 10 MG
Product Images
Rac1 Inhibitor | CAS 1177865-17-6 | Calbiochem | 10 MG
Description:
Rac1 Inhibitor | CAS 1177865-17-6 | Calbiochem | 10 MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
10 MG
Background Information:
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering their interaction with the Rac-specific GEF (guanine nucleotide exchange factor) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Exhibits no effect on Cdc42 or RhoA activation, and does it affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively). A 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553508) in H2O is also available.
Applications:
The Rac1 Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
530.96
CAS No.:
1177865-17-6
Brand Family:
Calbiochem
Presentation:
Lyophilized. Packaged under inert gas.
Storage Conditions:
Shipped at Ambient Temperature. Store at +2 - 8°C.
Properties:
Solubility: H2O (5 mg/ml).
PubChem ID:
26759436
Product Name:
Rac1 Inhibitor | CAS 1177865-17-6 | Calbiochem | 10 MG
Empirical Formula:
C24H38Cl3N7