Ordering Information
- : 559389-10MG
- : 10 MG
Product Images
SB 203580 (SB203580) | CAS 152121-47-6 | Calbiochem | 10MG
Description:
SB 203580 (SB203580) | CAS 152121-47-6 | Calbiochem | 10MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
10 MG
Background Information:
A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Reduces epirubicin-induced cell injury and caspase-3/7 activity. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
377.4
CAS No.:
152121-47-6
Brand Family:
Calbiochem
Presentation:
Thin film.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: DMSO (30 mg/ml).
Gene Symbol:
MAPK14, MAPK11
PubChem ID:
26759478
Product Name:
SB 203580 (SB203580) | CAS 152121-47-6 | Calbiochem | 10MG
Entrez Gene Number:
Empirical Formula:
C21H16N3OSF
Alternate Names:
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
- p38 MAP Kinase Inhibitor XVI