0 Items| Favorites
> Last Item Added:
0 Items

Ordering Information

  • : 662140-10MG
  • : 10 MG

Product Images

DUB Inhibitor IV, b-AP15 | Calbiochem | 10 MG

Description:
DUB Inhibitor IV, b-AP15 | Calbiochem | 10 MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
10 MG
Background Information:
A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50 = 2.1 μM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50 = 0.8 μM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5 mg/kg, i.p.).
Note: USP14-Proteasome Inhibitor, IU1 is also available (Cat. No. 662210).
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Molecular Weight:
419.4
Brand Family:
Calbiochem
Presentation:
Yellow solid. Packaged under inert gas.
Storage Conditions:
2 to 8°C. Protect from light. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Properties:
DMSO (100 mg/ml; clear, yellow solution)
Product Name:
DUB Inhibitor IV, b-AP15 | Calbiochem | 10 MG
Empirical Formula:
C22H17N3O6
Alternate Names:
  • (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
  • 3,5-bis((4-Nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one
  • NSC687852
  • USP14 Inhibitor III
    UCH-L5/UCH37 Inhibitor II
Purity:
≥97% by HPLC