Ordering Information
- : 688000-10MG
- : 10 MG
Product Images
Y-27632 (Y27632) | CAS 146986-50-7 | Calbiochem | 10MG
Description:
Y-27632 (Y27632) | CAS 146986-50-7 | Calbiochem | 10MG
Trade Name:
Calbiochem (EMD Millipore)
Qty/Pk:
10 MG
Background Information:
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O is also available.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular Weight:
338.3
CAS No.:
146986-50-7
Brand Family:
Calbiochem
Sales Restrictions:
Sold under license of U.S. Patent 4,997,834 and PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
Presentation:
White solid. Packaged under inert gas.
UniProt Number:
Storage Conditions:
Shipped at Ambient Temperature. Store at -20°C.
Properties:
Solubility: H2O (100 mg/ml).
Gene Symbol:
ROCK1, ROCK2
PubChem ID:
26759764
Product Name:
Y-27632 (Y27632) | CAS 146986-50-7 | Calbiochem | 10MG
Entrez Gene Number:
Empirical Formula:
C14H21N3O · 2HCl · H2O
Alternate Names:
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl
Purity:
≥95% by HPLC