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Ordering Information
- : AB10303
- : 50 µL
Product Images
Western Blot: Western Blot analysis of Rabbit anti-human CAR against human recombinant CAR at a dilution of 1:5000.
Anti-CAR
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rabbit | Serum | Polyclonal Antibody |
Description:
Anti-CAR
Trade Name:
Chemicon (Millipore)
Molecular Weight:
40kDa
Immunogen:
Recombinant human hCAR
Isotype:
IgG2b
Background Information:
The constitutive androstane receptor (CAR) plays a key role in the control of drug metabolism and transport. Its exact functionality is still under investigation and it is believed to function with PXR in the processing of xenobiotics.
Species Reactivity:
Human
Application Notes:
Suggested dilutions:
Western Blot: 1:5000
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw rabbit serum with 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C for up to 12 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- NR1I3
- MB67
- CAR
- CAR1
- MGC97209
- MGC150433
- CARA
- MGC97144
Alternate Names:
constitutive androstane receptor
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q14994 # Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
SIZE: 352 amino acids; 39942 Da
SUBUNIT: Heterodimer of NR1I3 and RXR. Interacts with PSMC4.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in liver.
DOMAIN:SwissProt: Q14994 Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
SIZE: 352 amino acids; 39942 Da
SUBUNIT: Heterodimer of NR1I3 and RXR. Interacts with PSMC4.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in liver.
DOMAIN:SwissProt: Q14994 Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
Qty/Pk:
50 µL
Brand Family:
Chemicon
Format:
Serum
Host:
Rabbit
Product Name:
Anti-CAR
Antibody Type:
Polyclonal Antibody