Ordering Information
- : AB119
- : 100 µL
Anti-Dopa Decarboxylase
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, Ca, H, R, Sh | WB | Sheep | Affinity Purified | Polyclonal Antibody |
Description:
Anti-Dopa Decarboxylase
Trade Name:
Chemicon (Millipore)
Specificity:
DOPA Decarboxylase (DDC). Reacts with a single band of ≈55 kDa by Western blot.
Bovine (high), human, sheep, canine, guinea pig, rat and rabbit (low), adrenal samples
Bovine (high), human, sheep, canine, guinea pig, rat and rabbit (low), adrenal samples
Immunogen:
Recombinant bovine DDC expressed in E. coli and purified from inclusion bodies.
Species Reactivity:
- Bovine
- Canine
- Human
- Rat
- Sheep
Application Notes:
Immunoblotting on adrenal, kidney and caudate nucleus samples: 1:500 - 1:1,000
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Presentation:
Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
Storage Conditions:
Maintain at -20 to -80°C in undiluted aliquots for up to six months. Store in a NON-self-defrosting freezer. Avoid repeated freeze-thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- DDC
- AADC
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P20711 # Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
COFACTOR: Pyridoxal phosphate.
SIZE: 480 amino acids; 53894 Da
SUBUNIT: Homodimer.
DISEASE: SwissProt: P20711 # Defects in DDC are the cause of aromatic-L-amino-acid decarboxylase deficiency (AADC deficiency) [MIM:608643]. AADC deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
SIMILARITY: SwissProt: P20711 ## Belongs to the group II decarboxylase family.
COFACTOR: Pyridoxal phosphate.
SIZE: 480 amino acids; 53894 Da
SUBUNIT: Homodimer.
DISEASE: SwissProt: P20711 # Defects in DDC are the cause of aromatic-L-amino-acid decarboxylase deficiency (AADC deficiency) [MIM:608643]. AADC deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
SIMILARITY: SwissProt: P20711 ## Belongs to the group II decarboxylase family.
Qty/Pk:
100 µL
Brand Family:
Chemicon
Format:
Affinity Purified
Host:
Sheep
Product Name:
Anti-Dopa Decarboxylase
Antibody Type:
Polyclonal Antibody