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NOGO Receptor representative staining pattern and morphology of rat brain tissue. Tissue pretreated with citrate pH 6, antigen retrieval. Antibody di...
NOGO Receptor staining of rat brain tissue found in literature. Cat. # AB15138 shows more plasma membrane staining due to its diffusive nature caused...
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Anti-Nogo Receptor
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R, H | WB, IH | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-Nogo Receptor
Specificity:
Cat. # AB15138 recognizes the mature form of Nogo Receptor.
Molecular Weight:
~50.9 kDa
Epitope:
Mature Form
Immunogen:
Recombinant protein.
Background Information:
Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.
Species Reactivity:
- Mouse
- Rat
- Human
Species Reactivity Note:
Mouse and rat. May react with human and primate based on sequence homology. Reactivity with other species has not been determined.
Application Notes:
Non-Lot Specific Tested Application 1:
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)
Control:
Mouse cerebellum lysate
Quality Assurance:
Routinely tested on mouse cerebellum lysate.
Lot Specific Tested Application 1: Western Blot
Lot Specific Tested Application 1: Western Blot
Purification Method:
Protein A purfied
Presentation:
Purified in PBS with 0.1% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- Foocen
- KIAA0886
- NI220/250
- NOGO
- NOGO-A
- NOGOC
- NSP
- NSP-CL
- Nbla00271
- Nbla10545
- Nogo-B
- Nogo-C
- RTN-X
- RTN-x
- RTN4-A
- RTN4-B1
- RTN4-B2
- RTN4-C
- Reticulon-5
Alternate Names:
- Human NogoA
- My043 protein
- Neurite outgrowth inhibitor
- Neuroendocrine-specific protein
- Neuroendocrine-specific protein C homolog
- Nogo protein
- neurite growth inhibitor 220
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
- Western Blotting
- Immunohistochemistry
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Product Name:
Anti-Nogo Receptor
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody