Anti-Hey 2/HRT2

Anti-Hey 2/HRT2

Chemicon (Millipore)

100 µg

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined

Western Blotting

Optimal working dilutions must be determined by the end user.

Human

Human. May react with pig, primate, horse, rat and mouse based on sequence homology. Reactivity with other species has not been determined.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

FUNCTION: SwissProt: Q9UBP5 # Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
SIZE: 337 amino acids; 35808 Da
SUBUNIT: May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
SUBCELLULAR LOCATION: Nucleus (By similarity).
DISEASE:SwissProt: Q9UBP5 # Defects in HEY2 may be involved in atrioventricular septal defects (AVSD).
SIMILARITY: SwissProt: Q9UBP5 ## Belongs to the HEY family. & Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 Orange domain.

36 kDa

Routinely tested on human testis tissue lysate

Synthetic Linear Peptide Toward C Terminus

Chemicon

human testis tissue lysate

Affinity Purified

Purified in PBS with 0.05% NaN3

Q9UBP5

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Rabbit

• HEY2
• BHLHB2
• BHLHB3
• HES1
• HES2

Neurobiology

Anti-Hey 2/HRT2

hairy/enhancer-of-split

See Data Sheet

Polyclonal Antibody

Cat. # AB15632 recognizes Hey 2/HRT2 protein.