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Ordering Information
- : AB2218
- : 100 μg
- : 1.0 mg/mL
Product Images
Western Blot Analysis:
Cat. # AB2218 can detect Aquaporin 4 at 0.5 µg/mL in adult rat brain Lysate.
Anti-Aquaporin 4
Recommended Replacement for: Cat. # AB3068| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-Aquaporin 4
Replaces:
Cat. # AB3068
Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes Aquaporin 4.
Molecular Weight:
~34 kDa
Epitope:
C-Terminus
Immunogen:
Synthetic Linear Peptide
Background Information:
The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
Species Reactivity:
Rat
Species Reactivity Note:
The antibody has not yet been tested for cross-reactivity to other species.
The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
Application Notes:
Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Control:
- Tested on adult rat brain lysate
Purification Method:
Immunoaffinity purified
Presentation:
Purified in PBS with 0.05% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- AQP4
- MIWC
- WCH4
- AQP-4
- aquaporin-4
- HMIWC2
- Aquaporin-4
- MGC22454
Alternate Names:
AQP4; WCH4; MIWC
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P55087 # Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
SIZE: 323 amino acids; 34830 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
SIZE: 323 amino acids; 34830 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Product Name:
Anti-Aquaporin 4
Concentration:
1.0 mg/mL
Antibody Type:
Polyclonal Antibody