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Western Blot Analysis:
Cat. # AB2218 can detect Aquaporin 4 at 0.5 µg/mL in adult rat brain Lysate.
Anti-Aquaporin 4
Recommended Replacement for: Cat. # AB3068| Reatividade à Espécie | Aplicações Essenciais | Hospedeiro | Formato | Tipo de Anticorpo |
|---|---|---|---|---|
| R | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Número Uniprot:
UniProt Summary
FUNCTION: SwissProt: P55087 # Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
SIZE: 323 amino acids; 34830 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains an ... see more »
SIZE: 323 amino acids; 34830 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain - muscle > heart, kidney, lung, and trachea.
DOMAIN: SwissProt: P55087 Aquaporins contain two tandem repeats each containing three membrane-spanning domains an ... see more »
Número Genbank:
Entrez Gene Summary
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Description:
Anti-Aquaporin 4
Replaces:
Cat. # AB3068
Background Information:
The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
Alternate Names:
AQP4; WCH4; MIWC
Specificity:
Recognizes Aquaporin 4.
Key Applications:
Western Blotting
Application Notes:
Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Species Reactivity:
Rat
Species Reactivity Note:
The antibody has not yet been tested for cross-reactivity to other species.
The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
Immunogen:
Synthetic Linear Peptide
Epitope:
C-Terminus
Molecular Weight:
~34 kDa
Control:
- Tested on adult rat brain lysate
Presentation:
Purified in PBS with 0.05% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Gene Symbol:
- AQP4
- MIWC
- WCH4
- AQP-4
- aquaporin-4
- HMIWC2
- Aquaporin-4
- MGC22454
Antibody Category:
Neuroscience
Antibody Sub-Category:
Ion Channels & Transporters
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format Code:
APur
Concentration:
1.0 mg/mL
Antibody Type:
Polyclonal Antibody
Format:
Affinity Purified
Host:
Rabbit
Purification Method:
Immunoaffinity Purified