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Western Blot Analysis:
Nonstimulated PC12 lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Norepinephrine Transpo...
Anti-Norepinephrine Transporter
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | WB | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-Norepinephrine Transporter
Specificity:
Cat. # AB2234 recognizes norepinephrine transporter
Molecular Weight:
~69 kDa
Immunogen:
Synthetic Linear Peptide
Background Information:
The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. In the CNS, norepinephrine is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, norepinephrine is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Certain antidepressant medications act to raise norepinephrine, such as the SNRIs and the tricyclic antidepressants (TCAs). In essence, these medications prevent the norepinephrine transporter from serving its purpose. Norepinephrine therefore remains in the synapse longer, allowing it to reach more normal levels. Since the norepinephrine transporter is also thought to transport dopamine to some extent, SNRIs would also raise dopamine levels in the synapse.
Species Reactivity:
Rat
Species Reactivity Note:
Rat. May react with human, mouse, dog and cow based on sequence homology. Reactivity with other species has not been determined.
Control:
PC12 lysate.
Quality Assurance:
Routinely evaluated by western blot.
Purification Method:
Immunoaffinity purified
Presentation:
Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- NAT1
- NET
- NET1
- SLC6A5
Alternate Names:
- Norepinephrine transporter
- noradrenaline transporter
- solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
- solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5
- solute carrier family 6 member 2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]
Key Applications:
Western Blotting
UniProt Summary:
LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Product Name:
Anti-Norepinephrine Transporter
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody