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Western Blot Analysis:
P1 Rat Brain lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Taurine Transporter (1:250)....
Anti-Taurine Transporter
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | WB | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-Taurine Transporter
Specificity:
Cat. AB2235 recognizes Taurine Transporter.
Molecular Weight:
65-70 kDa
Immunogen:
Synthetic Linear Peptide.
Background Information:
Taurine (2-aminoethane sulfonic acid), a beta-amino acid with a negatively charged sulfonic group is one of the most abundant amino acid in the brain. It is particularly enriched in excitable tissues, particularly those that generate oxidants. Taurine is produced by cysteine metabolism and obtained from diet as well. It is chemically inert molecule with a long turnover rate. It is not incorporated into proteins. It is thought to pay a major role in osmoregulation. It is also postulated to play a critical role in neurotransmission, neuromodulation, and membrane stabilization, neuronal differentiation, migration, synaptogenesis, and development. Taurine is transported to various target tissues by Na-dependent high affinity uptake system carried out in two distinct membrane transporter proteins: a high affinity (Km 40 uM) taurine transporter (TAU-1 or TAUT-1) and a beta-alanine and taurine transporter protein (Km 4.5 uM) known as TAUT-2 . Both TAUT-1/2 share significant sequence homology with the GABA and Glycine transporters that are characterized by the presence of 12 transmembrane domains. Taurine transporters are found in brain, retina and many other tissues.
Species Reactivity:
Rat
Species Reactivity Note:
Rat. May react with mouse based on sequence homology.
Control:
Rat P1 brain.
Quality Assurance:
Routinely tested on western blot.
Presentation:
Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- MGC10619
- MGC131729
- TAUT 1
Alternate Names:
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: Required for the uptake of taurine.
LOCATION: Membrane; Multi-pass membrane protein.
SPECIFICITY: Brain and peripheral tissues.
PTM: Down-regulated upon Ser-322 phosphorylation (By similarity).
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.
LOCATION: Membrane; Multi-pass membrane protein.
SPECIFICITY: Brain and peripheral tissues.
PTM: Down-regulated upon Ser-322 phosphorylation (By similarity).
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Product Name:
Anti-Taurine Transporter
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody