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Ordering Information
- : AB2249
- : 100 µg
- : 1 mg/mL
Product Images
Western Blot Analysis:
Mouse Heart lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Crim1 (0.5 ug/mL). Proteins...
Anti-CRIM1
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | WB | Rabbit | Purified | Polyclonal Antibody |
Description:
Anti-CRIM1
Specificity:
Cat. # AB2249 recognizes extracellular domain of CRIM1.
Molecular Weight:
100 kDa
Epitope:
Extracellular Domain
Immunogen:
Synthetic Linear Peptide
Background Information:
Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180)
families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM]
families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM]
Species Reactivity:
Mouse
Species Reactivity Note:
Mouse. May react with rat, dog, chicken, horse, opposum and human based on sequence homology. Reactivity with other species has not been determined.
Control:
Mouse heart lysate.
Quality Assurance:
Routinely evaluated by western blot on mouse heart lysate.
Presentation:
Purified in PBS with 0.05% NaN3
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- CRIM-1
- MGC138194
- S52
Alternate Names:
- Cysteine-rich repeat-containing protein S52
- cysteine rich transmembrane BMP regulator 1 (chordin-like)
- cysteine-rich motor neuron 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed Sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM]
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity).
SUBUNIT: Interacts with BMP4 and BMP7 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
SPECIFICITY: Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.
DEVELOPMENTAL STAGE: Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.
SIMILARITY: Contains 4 antistasin-like domains.
SIMILARITY: Contains 1 IGFBP N-terminal domain.
SIMILARITY: Contains 6 VWFC domains.
SUBUNIT: Interacts with BMP4 and BMP7 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
SPECIFICITY: Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis.
DEVELOPMENTAL STAGE: Detected in embryo at 11.5 dpc to 17.7 dpc with a maximum between 12.5 and 13.5 dpc.
SIMILARITY: Contains 4 antistasin-like domains.
SIMILARITY: Contains 1 IGFBP N-terminal domain.
SIMILARITY: Contains 6 VWFC domains.
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Product Name:
Anti-CRIM1
Concentration:
1 mg/mL
Antibody Type:
Polyclonal Antibody