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Western Blot Analysis:
Cat. # AB2250 can detect Eph A2/A3/A4/A5, phospho (Y596/602) at dilutions of 1:1,000.
Arrow corresponds to MW of ap...
Anti-Eph A2/A3/A4/A5, phospho (Tyr 596/602)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
Description:
Anti-Eph A2/A3/A4/A5, phospho (Tyr 596/602)
Specificity:
Cat. # AB2250 recognizes Eph A2/A3/A4/A5, phospho (Tyr 596/602)
Molecular Weight:
~ 140 kDa
Epitope:
Cytoplasmic Domain
Immunogen:
Synthetic Linear Peptide.
Modifications:
Phosphorylation
Background Information:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Species Reactivity:
Human
Species Reactivity Note:
Human. May react with mouse, rat, horse cow, chicken, monkey, dog and Xenopus based on sequence homology. Reactivity with other species has not been determined.
Control:
A431 Cell lysate.
Quality Assurance:
Routinely evaluated by western blot in A431 cell lysate
Purification Method:
Immunoaffinity purified
Presentation:
Purified in PBS with .07% Azide and 30% Glycerol.
Storage Conditions:
Maintain at -20°C for up to 1 year from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- ECK
- EphA2
Alternate Names:
- Tyrosine-protein kinase receptor ECK
- Epithelial cell kinase
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. [provided by RefSeq]
Key Applications:
Western Blotting
Qty/Pk:
100 µL
Format:
Affinity Purified
Host:
Rabbit
Product Name:
Anti-Eph A2/A3/A4/A5, phospho (Tyr 596/602)
Concentration:
0.22 mg/mL
Antibody Type:
Polyclonal Antibody