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Chicken anti-Myelin Basic Protein (Cat. No. AB9348). Staining of Myelin Basic Protein (green) in cells cultured from mouse embryonic 13.5 day cerebra....
Anti-Myelin Basic Protein
| Espèces réactives | Principales applications | Hôte | Forme | Type d'anticorps |
|---|---|---|---|---|
| H, M | IC, IH | Chicken | Affinity Purified | Polyclonal Antibody |
Code UniProt:
UniProt Summary
FUNCTION: SwissProt: P02686 # The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination
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Code GenBank:
Entrez Gene Summary
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP
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Description:
Anti-Myelin Basic Protein
Specificity:
Recognizes Myelin Basic Protein (MBP).
Key Applications:
- Immunocytochemistry
- Immunohistochemistry
Application Notes:
Immunohistochemistry: 1:50-1:100 using 2% paraformaldehyde fixed tissues.
Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by the end user.
Species Reactivity:
- Human
- Mouse
Immunogen:
Synthetic peptide from human/mouse MBP.
Presentation:
Affinity purified chicken IgY. Liquid in PBS, pH 7.2 with 0.02% sodium azide.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. It is recommended that you store the antibody in the dark.
Gene Symbol:
- MBP
- MGC99675
- Golli-mbp
Antibody Category:
Neuroscience
Antibody Sub-Category:
- Neuronal & Glial Markers
- Neurochemistry & Neurotrophins
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Affinity Purified
Host:
Chicken
Concentration:
0.1 mg/mL
Antibody Type:
Polyclonal Antibody