Ordering Information
- : AB9908
- : 100 μL
Anti-QKI-7
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | IP, WB | Rabbit | null | Polyclonal Antibody |
Description:
Anti-QKI-7
Trade Name:
Chemicon (Millipore)
Specificity:
QKI-7 (Quaking Protein). The antibody recognizes the ~42 kDa protein.
Immunogen:
Synthetic peptide from mouse QKI-7.
Background Information:
QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.
Species Reactivity:
- Human
- Mouse
- Rat
Control:
Positive Control: Glial cells, astrocytes and oligodendrocytes.
Purification Method:
Serum
Presentation:
Liquid.
Storage Conditions:
Maintain at -20°:C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- QKI
- DKFZp586I0923
- Hqk
- QK3
- QK
- HKQ
- HqkI
Alternate Names:
Quaking Protein
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]).[supplied by OMIM]
Key Applications:
- Immunoprecipitation
- Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q96PU8 # RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
SIZE: 341 amino acids; 37671 Da
SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in the frontal cortex of brain.
PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors.
SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain.
SIZE: 341 amino acids; 37671 Da
SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in the frontal cortex of brain.
PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).
DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors.
SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain.
Qty/Pk:
100 μL
Brand Family:
Chemicon
Host:
Rabbit
Protein/Isoform Description:
QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B to promote oligedendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA.It is regulated by alternative splicing.
Product Name:
Anti-QKI-7
Antibody Type:
Polyclonal Antibody