Ordering Information
- : CBL1506F
- : 100 assays
Anti-CD4, clone OX-38, FITC conjugated
Recommended Replacement for: CBL1506P| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | FC, IH | Mouse | FITC | Monoclonal Antibody |
Description:
Anti-CD4, clone OX-38, FITC conjugated
Replaces:
CBL1506P
Trade Name:
Chemicon (Millipore)
Specificity:
This antibody detects the CD4 antigen present on a subset of T cells that has suppressor and cytotoxic activities. 90% of thymocytes and NK cells are labelled with this antigen. OX-38 antibody binds to the same epitope of CD4 as the clone W3/25 which differs from the CD4 epitope recognized by OX-35
Clone:
OX-38
Isotype:
IgG2a
Species Reactivity:
Rat
Application Notes:
Flow cytometry.
The study of phenotypes of T cells mediating various T cell functions.
Optimal working dilutions must be determined by the end user.
The study of phenotypes of T cells mediating various T cell functions.
Optimal working dilutions must be determined by the end user.
Presentation:
The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
Storage Conditions:
Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- CD4
- CD4mut
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
- Flow Cytometry
- Immunohistochemistry
UniProt Summary:
FUNCTION: SwissProt: P01730 # Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
SIZE: 458 amino acids; 51111 Da
SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
MISCELLANEOUS: Primary receptor for HIV-1."
SIZE: 458 amino acids; 51111 Da
SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
MISCELLANEOUS: Primary receptor for HIV-1."
Qty/Pk:
100 assays
Brand Family:
Chemicon
Format:
FITC
Host:
Mouse
Product Name:
Anti-CD4, clone OX-38, FITC conjugated
Antibody Type:
Monoclonal Antibody