Anti-CD36, FITC conjugated, clone SM-phi, FITC conjugated

Anti-CD36, FITC conjugated, clone SM-phi, FITC conjugated

Chemicon (Millipore)

This antibody recognizes the 90 kDa single chain membrane glycoprotein (GPIIIb) that is found on monocytes/macrophages and platelets. FUSION PARTNER: NS1 myeloma cell line

Human tonsil cells and peripheral blood mononuclear cells

SM-phi

IgM

Human

Studies of platelet and monocyte receptor for thrombospondin

Studies of platelet collagen adhesion receptor

Flow cytometry

Optimal working dilutions must be determined by the end user.

The monoclonal was purified by affinity chromatography and gel filtration prior to conjugation. The conjugate is supplied in 1.0 ml of phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.

Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C for up to one year.

P16671

• NM_000072.2
• NM_001001547.1
• NM_001001548.1

• CD36
• PAS-4
• GPIV
• FAT
• CHDS7
• GP3B
• SCARB3
• PASIV
• GP4
• GPIIIB

Platelet Glycoprotein IV

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

• Flow Cytometry
• Immunohistochemistry

FUNCTION: SwissProt: P16671 # Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
SIZE: 472 amino acids; 53053 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: N-glycosylated and O-glycosylated with a ratio of 2:1.
DISEASE: SwissProt: P16671 # Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. & Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
SIMILARITY: SwissProt: P16671 ## Belongs to the CD36 family.

100 assays

Chemicon

FITC

Mouse

Anti-CD36, FITC conjugated, clone SM-phi, FITC conjugated

Monoclonal Antibody