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  • : CBL234F
  • : 100 assays
  • Product Family Information

Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated

Species Reactivity Key Applications Host Format Antibody Type
B, H, R, Fg IH(P) Mouse FITC Monoclonal Antibody
Description:
Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated
Promotional Text:
Trade Name:
Chemicon (Millipore)
Specificity:
The antibody reacts specifically with a wide range of normal, reactive and neoplastic epithelial tissues.

KNOWN SPECIES CROSS REACTIVITY: Positive with bovine, rat and frog
Immunogen:
Epidermal carcinoma cell line A431
Clone:
Isotype:
Species Reactivity:
  • Bovine
  • Human
  • Rat
  • Frog
Application Notes:
Western blotting

Pan epithelial reactivity on frozen sections

Methanol/acetone fixed cultured epithelial cells

Suitable for staining formalin fixed paraffin wax sections following proteolytic enzyme digestion

Optimal working dilutions must be determined by the end user.
Presentation:
The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
Storage Conditions:
Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
  • KRT4
  • Cytokeratin-4
  • CK-4
  • CK4
  • CYK4
  • Keratin-4
  • K4
  • FLJ31692
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
UniProt Summary:
FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
SIZE: 483 amino acids; 53704 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Brand Family:
Chemicon
Product Name:
Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 assays
Target / Localization:
Pan-keratin
Format:
Host:
Mouse
Applications:
Anti-Cytokeratin Pan Antibody, clone C11, FITC conjugated is an antibody against Cytokeratin Pan for use in IH(P).

Product Resources

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