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Tenascin is known to play a role in development of the CNS and mesenchymal-derived organs, exist in vasculature of tumors in adults and function in ce...
Human Tenascin-C Purified Protein
Recommended Replacement for: CC066Description:
Human Tenascin-C Purified Protein
Trade Name:
Chemicon (Millipore)
Qty/Pk:
100 µg
Product Overview:
Purified Human Tenascin-C Protien. Tenascin is known to: 1) play an active role in development of central nervous system and mesenchymal-derived organs; 2) exist in vasculature of tumors in adults; and 3) function in cell adhesion. By SDS-PAGE analysis, the protein migrates around 280-300kD.
Key Applications:
- Positive Control
- Cell Culture
Application Notes:
Cell adhesion assays.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UniProt Summary:
FUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
SIZE: 2201 amino acids; 240866 Da
SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
SIZE: 2201 amino acids; 240866 Da
SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
Species:
Human
Stem Cell Type:
- Human Embryonic Stem Cells
- Mesenchymal Stem Cells
- Neural Stem Cells
- Hematopoietic Stem Cells
- Epithelial Cells
- Pancreatic Stem Cells
- Induced Pluripotent Stem Cells
Stem Cell Workflow Stage:
- Maintenance & Expansion
- General Cell Culture
- Differentiation
Brand Family:
Chemicon
Source:
Human glioma cell line (U251).
Presentation:
Purified protein supplied as a liquid in PBS containing no preservatives.
UniProt Number:
Storage Conditions:
Maintain at -70ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
Cell Culture Reagent Type:
- Stem Cell Reagents
- Attachment Factors
Replaces:
CC066
Gene Symbol:
- TNC
- Hexabrachion
- HXB
- GMEM
- TN
- Neuronectin
- Tenascin-C
- MGC167029
- JI
- TN-C
- Cytotactin
Protein or Enzyme Type:
Extracellular Matrix Proteins
Product Name:
Human Tenascin-C Purified Protein
Entrez Gene Number:
Alternate Names:
TN-C; Tenascin; Hexabrachion; Cytotactin; Neuronectin
Concentration:
0.1 mg/mL
Purity:
> 97% pure by SDS-PAGE