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Reducing SDS-PAGE of 2.5 ug purified chicken tenascin (CC115) illustrating a major band at 220 kDa, with doublet at 200 kDa.
Chicken Tenascin
Description:
Chicken Tenascin
Trade Name:
Chemicon (Millipore)
Qty/Pk:
100 µg
Product Overview:
Tenascin is a large glycoprotein that forms disulfide-linked hexamers. It is made up of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels. Tenascin binds to several cell-surface receptors and mediates cell-substrate adhesion. Nevertheless, tenascin is frequently referred to as an anti-adhesion molecule because for a variety of cell types the presence of tenascin inhibits adhesion to other ECM proteins present. This effect occurs because the binding of tenascin to certain receptors inhibits cell spreading and thereby blocks the stabilization of adhesion that results from cell preading in vitro assays.
Key Applications:
- Positive Control
- Cell Culture
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Species:
Chicken
Stem Cell Type:
- Mouse Embryonic Stem Cells
- Mesenchymal Stem Cells
- Neural Stem Cells
- Hematopoietic Stem Cells
- Epithelial Cells
- Pancreatic Stem Cells
- Induced Pluripotent Stem Cells
Stem Cell Workflow Stage:
- Maintenance & Expansion
- General Cell Culture
- Differentiation
Brand Family:
Chemicon
Presentation:
Provided as a liquid in PBS, containing no preservatives.
UniProt Number:
Storage Conditions:
Store at -20°C for up to 12 months. Avoid repeated freeze/thaw.
Cell Culture Reagent Type:
Attachment Factors
Protein or Enzyme Type:
Extracellular Matrix Proteins
Product Name:
Chicken Tenascin
Alternate Names:
Cytotactin; Tenascin-C
Concentration:
0.755 mg/mL
Purity:
Isolated from embryonic chicken brains by chromatographic methods. Contains three characteristic polypeptide chains (220, 200, and 190 kDa) that migrate on SDS gels as a high molecular weight multimer under non-reducing conditions.