ArthroMAB; Kit, 1 mouse
Recommended Replacement for: ECM1004Description:
ArthroMAB; Kit, 1 mouse
Replaces:
ECM1004
Key Applications:
- Activity Assay
- Affects Function
Species Reactivity:
Mouse
Presentation:
The antibody cocktail contains 10 mM Sodium Phosphate, 125 mM NACL, pH 7.1 with no preservatives.
Storage Conditions:
Materials should be stored at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw of monoclonal antibodies.
Precautions:
· LPS is pyrogenic. This material should be handled by trained personnel with appropriate laboratory precautions.
Precautions:
· LPS is pyrogenic. This material should be handled by trained personnel with appropriate laboratory precautions.
Gene Symbol:
- COL2A1
- SEDC
- COL11A3
- ANFH
- MGC131516
- chondrocalcin
- AOM
Components:
- ArthroMAB Monoclonal Antibody Blend - (Catalog No. 1008546) 0.4 mL of monoclonal antibody cocktail solution containing 1 mg each of four monoclonal antibodies (clones C11b, J1, D3 and U1) in sterile PBS. Total protein concentration = 10.0 mg/mL.
- LPS - (Catalog No. 90031) 2 vials containing 50 ug Lipopolysaccharide from E. coli strain 0111B4 dissolved in PBS at 1 mg/mL.
Antibody Category:
Inflammation & Immunology
Antibody Sub-Category:
Inflammation & Autoimmune Mechanisms
Usage Statement:
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- This product is manufactured for Millipore by MD Biosciences, Morwell Diagnostics, Switzerland.
Descriptive Text:
Trade Name:
Chemicon (Millipore)
Product Overview:
Collagen-induced arthritis (CIA) in mice is widely used as an experimental model for rheumatoid arthritis (RA) in humans. CIA is mediated by autoantibodies, which bind to a particular region of type II collagen, such as CB11 (CNBR-digested fragment of type II collagen) (Terato et al, 1985).
Antibody-mediated CIA can be induced by i.v. injection of a combination of four different monoclonal antibodies generated by the ArthroMAB mouse B-hybridoma cell lines.
T In the mouse CIA model, the antibody response that is correlated with arthritis is mainly associated with binding to the epitopes of C11b, J1 and U1. This cocktail of 4 purified mouse monoclonal antibodies bind to the well-defined epitopes C11b, J1, D3 and U1, which are spread over the entire CII (CB8, CB10 and CB11 fragments), possibly encouraging better immune complex formation on the cartilage surface for the initiation of arthritis (Terato et al, 1985).
Antibody-mediated CIA can be induced by i.v. injection of a combination of four different monoclonal antibodies generated by the ArthroMAB mouse B-hybridoma cell lines.
T In the mouse CIA model, the antibody response that is correlated with arthritis is mainly associated with binding to the epitopes of C11b, J1 and U1. This cocktail of 4 purified mouse monoclonal antibodies bind to the well-defined epitopes C11b, J1, D3 and U1, which are spread over the entire CII (CB8, CB10 and CB11 fragments), possibly encouraging better immune complex formation on the cartilage surface for the initiation of arthritis (Terato et al, 1985).
Antibody Type:
Monoclonal Antibody
Host:
Mouse