Product Images
Flow Cytometry Analysis:
Representative lot data.
FACS analysis of Jurkat cells stained with anti-T-bet FITC (green histogram) or non-spec...
Milli-Mark Anti-TBX21/T-Bet-FITC
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | FC | Rabbit | FITC | Polyclonal Antibody |
Description:
Milli-Mark Anti-TBX21/T-Bet-FITC Antibody | FCABS131F
Promotional Text:
Trade Name:
Milli-Mark
Specificity:
Antibody recognizes TBX21/T-Bet.
Molecular Weight:
58 kDa Observed
Epitope:
34-49
Immunogen:
KLH conjugated synthetic peptide corresponding to a.a. 34-49 of human T-Bet.
Background Information:
TBX21 (T-box transcription factor, also known as T-Bet) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Studies in mouse show that TBX21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with IFN-G expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. TBX21 initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps
Species Reactivity:
Human
Species Reactivity Note:
Tested and passed on Human. Unconjugated part number 09-717 is known to work with Mouse and Rat.
Control:
Jurkat cells
Quality Assurance:
Evaluated by flow cytometry using Jurkat cells.
Purification Method:
Antigen affinity purified
Presentation:
Purified rabbit polyclonal conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Alternate Names:
TBX21
T-Bet
T-box transcription factor
T-box 21
T-Bet
T-box transcription factor
T-box 21
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Flow Cytometry
Product Name:
Milli-Mark Anti-TBX21/T-Bet-FITC
Concentration:
0.5 mg/mL
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 tests
Format:
FITC
Host:
Rabbit