Product Images
Flow Cytometry Analysis:
Representative lot data.
FC analysis of B35 cells stained with Anti-NR2B, FITC conjugated. Cells were stained wi...
Milli-Mark™ Anti-NR2B-FITC
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| Rb, B, Ca, H, Mk, R | FC | Rabbit | FITC | Polyclonal Antibody |
Description:
Milli-Mark™ Anti-NR2B-FITC
Trade Name:
Milli-Mark
Specificity:
Antibody recognizes Mouse NR2B.
Molecular Weight:
166.3 kDa Calculated
Immunogen:
Linear peptide corresponding to mouse NR2B.
Isotype:
IgG
Background Information:
NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B or NR2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.
Species Reactivity:
- Rabbit
- Bovine
- Canine
- Human
- Monkey
- Rat
Species Reactivity Note:
Tested and passed on Rabbit. Predicted on Bovine, Canine, Human, Monkey, Rat based on 100% sequence homology.
Control:
B35 cells
Quality Assurance:
Evaluated by flow cytometry using B35 cells.
Purification Method:
Protein A Purified
Presentation:
Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- MGC142178
- MGC142180
- NMDAR2B
- NR3
- hNR3
- GRIN2B
Alternate Names:
- N-methyl D-aspartate receptor subtype 2B
- N-methyl-D-aspartate receptor subunit 2B
- N-methyl-D-aspartate receptor subunit 3
- glutamate receptor subunit epsilon-2
- glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Flow Cytometry
UniProt Summary:
FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
Product Name:
Milli-Mark™ Anti-NR2B-FITC
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 tests
Format:
FITC
Host:
Rabbit