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Flow Cytometry Analysis:
Representative lot data.
FACS analysis using HeLa cells, stained with anti-FXR1 antibody (green), or Biolegend 400...
Milli-Mark Anti-FXR1 -FITC, clone 6BG10
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | FC | Mouse | FITC | Monoclonal Antibody |
Description:
Milli-Mark Anti-FXR1 -FITC Antibody, clone 6BG10 | FCMAB152F
Promotional Text:
Trade Name:
Milli-Mark
Specificity:
Antibody recognizes FXR1.
Molecular Weight:
~68 kDa Observed
Epitope:
Unknown
Immunogen:
Recombinant protein corresponding to human FXR1.
Clone:
6BG10
Isotype:
IgG2aκ
Background Information:
Fragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
Species Reactivity:
Human
Species Reactivity Note:
Tested and passed on Human.
Control:
HeLa Cells
Quality Assurance:
Evaluated by flow cytometry using using HeLa cells.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG2aκ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
FXR1
hFXR1
hFXR1
Alternate Names:
fragile X mental retardation, autosomal homolog 1
fragile X mental retardation-related protein 1
fragile X mental retardation-related protein 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Flow Cytometry
Entrez Gene Summary:
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Summary:
FUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs By similarity.
SUBUNIT STRUCTURE: Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICTY: Expressed in all tissues examined including heart, brain, kidney and testis.
PTM: Arg-445 is dimethylated, probably to asymmetric dimethylarginine.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Contains 2 KH domains
SUBUNIT STRUCTURE: Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICTY: Expressed in all tissues examined including heart, brain, kidney and testis.
PTM: Arg-445 is dimethylated, probably to asymmetric dimethylarginine.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Contains 2 KH domains
Product Name:
Milli-Mark Anti-FXR1 -FITC, clone 6BG10
Concentration:
0.5 mg/mL
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 tests
Format:
FITC
Host:
Mouse