Product Images
Flow Cytometry Analysis:
Representative lot data.
FC analysis of mouse spleen cells stimulated with PMA and Ionomycin and stained with a P...
Milli-Mark™ Anti-mouse Interleukin-4-PE, clone 11B11
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | FC | Rat | Phycoerythrin | Monoclonal Antibody |
Description:
Milli-Mark™ Anti-mouse Interleukin-4-PE, clone 11B11
Trade Name:
Milli-Mark
Specificity:
Antibody recognizes IL-4.
Molecular Weight:
15 kDa Calculated
Immunogen:
Recombinant protein corresponding to mouse IL-4.
Clone:
11B11
Isotype:
IgG1κ
Background Information:
Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
Species Reactivity:
Mouse
Species Reactivity Note:
Tested and passed on mouse.
Control:
Mick2 cells
Quality Assurance:
Evaluated by flow cytometry using Mick2 cells.
Purification Method:
Protein G Purified
Presentation:
Purified rat monoclonal IgG1κ conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- IL4
- Binetrakin
- Pitrakinra
- BSF1
- BSF-1
- IL-4
Alternate Names:
- B cell growth factor 1
- B-cell stimulatory factor 1
- B_cell stimulatory factor 1
- Lymphocyte stimulatory factor 1
- interleukin 4
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Flow Cytometry
UniProt Summary:
FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
Product Name:
Milli-Mark™ Anti-mouse Interleukin-4-PE, clone 11B11
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 tests
Format:
Phycoerythrin
Host:
Rat