Ordering Information
- : FCMAB426PE
- : 100 tests
Product Images
Flow Cytometry Analysis:
Representative lot data #1.
FC analysis of mouse splenocytes stained with anti-mouse CD44-PE (yellow) versus isot...
Flow Cytometry Analysis:
Representative lot data #2.
FC analysis of mouse bone marrow stained with anti-mouse CD44-PE (yellow) versus isot...
Milli-Mark® Anti-mouse CD44 (H-CAM)-PE, clone KM201
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | FC | Rat | Phycoerythrin | Monoclonal Antibody |
Description:
Milli-Mark® Anti-mouse CD44 (H-CAM)-PE Antibody, clone KM201 | FCMAB426PE
Promotional Text:
Specificity:
The antibody recognizes CD44 near the hyaluronate binding domain.
Molecular Weight:
Antibody recognizes multiple isoforms for mouse CD44, calculated molecular weights ranging from 40 to 85 kDa.
Epitope:
Near the hyaluronate binding domain
Immunogen:
Mouse bone marrow-derived stromal cells
Clone:
KM201
Isotype:
IgG1κ
Background Information:
CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
Species Reactivity:
Mouse
Species Reactivity Note:
Tested and passed on Mouse.
Control:
mouse splenocytes
Quality Assurance:
Evaluated by flow cytometry using mouse splenocytes
Purification Method:
Protein G Purified
Presentation:
Purified rat monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- CD44
- CD44R
- CDW44
- CDw44
- CSPG8
- ECMR-III
- Epican
- HCELL
- HUTCH-I
- IN
- LHR
- MC56
- MDU2
- MDU3
- MIC4
- MUTCH-I
- PGP-1
- PGP-I
- Pgp1
Alternate Names:
- CD44 antigen (homing function and Indian blood group system)
- CDw44 antigen
- HCAM
- H-CAM
- HUTCH-1
- Phagocytic glycoprotein I
- Extracellular matrix receptor III
- GP90 lymphocyte homing/adhesion receptor
- Heparan sulfate proteoglycan
- Hermes antigen
- Hyaluronate receptor
- Epican
- antigen gp90 homing receptor
- chondroitin sulfate proteoglycan 8
- hematopoietic cell E- and L-selectin ligand
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Flow Cytometry
UniProt Summary:
FUNCTION: Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: N-glycosylated By similarity.
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity).
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity).
POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).
SEQUENCE SIMILARITIES: Contains 1 Link domain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: N-glycosylated By similarity.
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity).
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity).
POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).
SEQUENCE SIMILARITIES: Contains 1 Link domain.
Product Name:
Milli-Mark® Anti-mouse CD44 (H-CAM)-PE, clone KM201
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 tests
Format:
Phycoerythrin
Host:
Rat