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ChemiSCREEN™ CCR2B Calcium-Optimized FLIPR Cell Lines
Description:
ChemiSCREEN™ CCR2B Calcium-Optimized FLIPR Cell Lines
Trade Name:
- ChemiScreen
- Chemicon (Millipore)
Qty/Pk:
2 vials
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
UniProt Summary:
FUNCTION: SwissProt: P41597 # Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
SIZE: 374 amino acids; 41915 Da
SUBUNIT: Binds to HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: N-glycosylated.
SIMILARITY: SwissProt: P41597 ## Belongs to the G-protein coupled receptor 1 family.
SIZE: 374 amino acids; 41915 Da
SUBUNIT: Binds to HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: N-glycosylated.
SIMILARITY: SwissProt: P41597 ## Belongs to the G-protein coupled receptor 1 family.
Species:
Human
Cell Type:
Chem-1
Cell Line Type:
GPCR Cell Lines
Brand Family:
Chemicon
Host Cells:
Chem-1
Protein Target:
CCR2B
Format:
Cell Line
UniProt Number:
Ligand Type:
peptide
Target Sub-Family:
Chemokine
Promotional Text:
For special offers Click here http://www.millipore.com/drugdiscovery/dd3/gpcrtargetsolutions
GPCR Class:
A
Packaging:
2 x 106 cells/vial
Gene Symbol:
- CCR2
- CC-CKR-2
- CCR2A
- CCR-2
- CKR2
- CKR2A
- MCP-1-R
- CCR2B
- CMKBR2
- CD192
- MCP-1
- CKR2B
Protein or Enzyme Type:
GPCRs
Product Name:
ChemiSCREEN™ CCR2B Calcium-Optimized FLIPR Cell Lines
Entrez Gene Number: