ChemiSCREEN™ CCR2B Membrane Preparation

ChemiSCREEN™ CCR2B Membrane Preparation

• ChemiScreen
• Chemicon (Millipore)

200 assays

Human

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This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

FUNCTION: SwissProt: P41597 # Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
SIZE: 374 amino acids; 41915 Da
SUBUNIT: Binds to HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: N-glycosylated.
SIMILARITY: SwissProt: P41597 ## Belongs to the G-protein coupled receptor 1 family.

Human

Chem-1

Chemicon

Chem-1

CCR2B

Membranes

P41597

peptide

Chemokine

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A

• CCR2
• CC-CKR-2
• CCR2A
• CCR-2
• CKR2
• CKR2A
• MCP-1-R
• CCR2B
• CMKBR2
• CD192
• MCP-1
• CKR2B

GPCR Membrane Preparations

ChemiSCREEN™ CCR2B Membrane Preparation

• NM_000647.4
• NM_000648.2

GPCR