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ChemiSCREEN™ CCR6 Calcium-Optimized FLIPR Cell Lines
Description:
ChemiSCREEN™ CCR6 Calcium-Optimized FLIPR Cell Lines
Trade Name:
- ChemiScreen
- Chemicon (Millipore)
Qty/Pk:
2 vials
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
UniProt Summary:
FUNCTION: SwissProt: P51684 # Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
SIZE: 374 amino acids; 42494 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
SIMILARITY: SwissProt: P51684 ## Belongs to the G-protein coupled receptor 1 family.
SIZE: 374 amino acids; 42494 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
SIMILARITY: SwissProt: P51684 ## Belongs to the G-protein coupled receptor 1 family.
Species:
Human
Cell Type:
Chem-1
Cell Line Type:
GPCR Cell Lines
Brand Family:
Chemicon
Host Cells:
Chem-1
Protein Target:
CCR6
Format:
Cell Line
UniProt Number:
Ligand Type:
peptide
Target Sub-Family:
Chemokine
Promotional Text:
For special offers Click here http://www.millipore.com/drugdiscovery/dd3/gpcrtargetsolutions
GPCR Class:
A
Packaging:
2 x 106 cells/vial
Gene Symbol:
- CCR6
- CKR-L3
- DRY6
- DRY-6
- BN-1
- CKR6
- GPR29
- DCR2
- GPR-CY4
- CD196
- CC-CKR-6
- STRL22
- GPRCY4
- CKRL3
- CCR-6
- CMKBR6
Protein or Enzyme Type:
GPCRs
Product Name:
ChemiSCREEN™ CCR6 Calcium-Optimized FLIPR Cell Lines
Entrez Gene Number: