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ChemiSCREEN™ CCR8 Calcium-Optimized FLIPR Cell Line
Description:
ChemiSCREEN™ CCR8 Calcium-Optimized FLIPR Cell Line
Trade Name:
- ChemiScreen
- Chemicon (Millipore)
Qty/Pk:
2 vials
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
UniProt Summary:
FUNCTION: SwissProt: P51685 # Receptor for the chemokine SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
SIZE: 355 amino acids; 40844 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P51685 ## Belongs to the G-protein coupled receptor 1 family.
SIZE: 355 amino acids; 40844 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P51685 ## Belongs to the G-protein coupled receptor 1 family.
Species:
Human
Cell Type:
Chem-1
Cell Line Type:
GPCR Cell Lines
Brand Family:
Chemicon
Host Cells:
Chem-1
Protein Target:
CCR8
Format:
Cell Line
UniProt Number:
Ligand Type:
peptide
Target Sub-Family:
Chemokine
Promotional Text:
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GPCR Class:
A
Packaging:
2x10(e6) cells/vial
Gene Symbol:
- CCR8
- CMKBR8
- MGC129973
- GPRCY6
- TER1
- CKR-L1
- CCR-8
- MGC129966
- CC-CKR-8
- CY6
- CKRL1
- CDw198
- CMKBRL2
- GPR-CY6
Protein or Enzyme Type:
GPCRs
Product Name:
ChemiSCREEN™ CCR8 Calcium-Optimized FLIPR Cell Line
Entrez Gene Number: