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ChemiScreen™ Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor
Description:
ChemiScreen™ Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor
Trade Name:
- ChemiScreen
- Chemicon (Millipore)
Qty/Pk:
200 units
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
UniProt Summary:
FUNCTION: SwissProt: P11229 # The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
SIZE: 460 amino acids; 51421 Da
SUBUNIT: Interacts with GPRASP2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P11229 ## Belongs to the G-protein coupled receptor 1 family.
SIZE: 460 amino acids; 51421 Da
SUBUNIT: Interacts with GPRASP2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P11229 ## Belongs to the G-protein coupled receptor 1 family.
Species:
Human
Cell Type:
Chem-1
Brand Family:
Chemicon
Host Cells:
Chem-1
Protein Target:
M1
Format:
Membranes
UniProt Number:
Ligand Type:
non-peptide
Target Sub-Family:
Acetylcholine (muscarinic)
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GPCR Class:
A
Gene Symbol:
- CHRM1
- MGC30125
- M1
- HM1
Protein or Enzyme Type:
GPCR Membrane Preparations
Product Name:
ChemiScreen™ Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor
Entrez Gene Number:
Cell Membrane Type:
GPCR