Anti-PAX8, clone 3G11

Anti-PAX8, clone 3G11

Chemicon (Millipore)

43 kDa

Recombinant human PAX8

3G11

IgG2b

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• Human
• Mouse

Optimal working dilutions must be determined by end user.

Liquid containing 0.1% sodium azide.

Maintain at 2-8°C for up to 12 months from date of receipt.

Q06710

• NM_003466.3
• NM_013951.3
• NM_013952.3
• NM_013953.3
• NM_013992.3

PAX8

Paired box protein Pax-8

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described.

Western Blotting

FUNCTION: SwissProt: Q06710 # Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
SIZE: 450 amino acids; 48119 Da
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in the excretory system, thyroid gland and Wilms tumors.
DEVELOPMENTAL STAGE: In developing excretory system, during thyroid differentiation and in adult thyroid.
DISEASE: SwissProt: Q06710 # Defects in PAX8 are a cause of thyroid dysgenesis (TD) [MIM:218700]. TD is the most frequent cause of congenital hypothyroidism (CH). The thyroid gland can be absent (athyreosis), ectopically located (most often at the base of the tongue) and/or severely reduced in size (hypoplasia).
SIMILARITY: SwissProt: Q06710 ## Contains 1 paired domain.

100 µg

Chemicon

Culture Supernatant

Mouse

Anti-PAX8, clone 3G11

Monoclonal Antibody