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Ordering Information
- : MAB1048
- : 100 µg
Anti-Bone Morphogenetic Protein 6, clone Morph-6.1
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | IH(P) | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-Bone Morphogenetic Protein 6, clone Morph-6.1
Trade Name:
Chemicon (Millipore)
Specificity:
Bone morphogenetic protein 6 (BMP-6) is a member of the TGF-b superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis. MAB1048 recognizes BMP-6. Pre-incubation of MAB1048 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the monoclonal to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as irrelevant peptides does not inhibit specific tissue staining. The antigen is highly conserved phylogenetically and is thus anticipated to react with most mammalian species.
Molecular Weight:
45/18 kDa
Immunogen:
Synthetic peptide vgr 1-29C-KLH.
Clone:
Morph-6.1
Isotype:
IgG1
Background Information:
Bone morphogenetic protein 6 (BMP6) is a polypetide that is a member of the TGF-β superfamily of proteins. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
Species Reactivity:
- Human
- Rat
Application Notes:
Immunohistochemistry: 1-5 μg/mL. Fixation: formaldehyde, paraffin. Tissue pretreatment: microwave treatment (6 x 5) min is required.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Control:
Embryonic and adult central nervous system, rat radial glial cells, fetal intestine, healing skin or chondrocytes
Presentation:
Purified immunoglobulin from culture supernatant. Lyophilized from PBS containing 5 mg/mL BSA and 0.09% sodium azide. Reconstitute with 0.5 mL of sterile distilled water.
Storage Conditions:
Maintain lyophilized material at 2-8°C for up to 12 months after date of receipt. After reconstitution maintain at -20*C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- BMP6
- VGR1
- BMP-6
- VGR
Alternate Names:
BMP-6; DVR-6 (Decapentaplegic Vegetal Related); vgr-1 (vegetal related)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Key Applications:
Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: SwissProt: P22004 # Induces cartilage and bone formation.
SIZE: 513 amino acids; 57226 Da
SUBUNIT: Interacts with SOSTDC1 (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: SwissProt: P22004 ## Belongs to the TGF-beta family.
SIZE: 513 amino acids; 57226 Da
SUBUNIT: Interacts with SOSTDC1 (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: SwissProt: P22004 ## Belongs to the TGF-beta family.
Stem Cell Type:
- Mesenchymal Stem Cells
- Neural Stem Cells
Stem Cell Workflow Stage:
Characterization
Qty/Pk:
100 µg
Brand Family:
Chemicon
Format:
Purified
Host:
Mouse
Product Name:
Anti-Bone Morphogenetic Protein 6, clone Morph-6.1
Antibody Type:
Monoclonal Antibody