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Primary keratinocytes on collagen treated EGF and alpha 2 antibody (Catalog Number MAB1950) 1:100.
Primary skin keratinocytes plated on collagen, treated with EGF 30 ug/mL (Negative control)
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Anti-Integrin α2, clone P1E6
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IC, IH, FUNC, not IH(P) | Mouse | Purified | Monoclonal Antibody |
Description:
Anti-Integrin α2, clone P1E6
Trade Name:
Chemicon (Millipore)
Specificity:
Reacts with Human a2 integrin.
Clone:
P1E6
Isotype:
IgG1
Species Reactivity:
Human
Application Notes:
Suitable for use in attachment inhibition assays using fibroblasts, epithelial cells, endothelial cells, and non-activated platelets on collagen types I, III, IV, VI and laminin.
Suitable for immunofluorescence using fresh frozen or acetone fixed tissues. Not recommended for traditional formalin fixed paraffin embedded tissues.
Final working dilutions must be determined by end user.
Suitable for immunofluorescence using fresh frozen or acetone fixed tissues. Not recommended for traditional formalin fixed paraffin embedded tissues.
Final working dilutions must be determined by end user.
Applications Not Recommended:
Immunohistochemistry (Paraffin)
Control:
Skin (Basement membrane)
Purification Method:
Protein A purfied
Presentation:
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Storage Conditions:
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Entrez Gene Number:
Gene Symbol:
- ITGA2
- CD49B
- VLAA2
- VLA-2
- CD49b
- BR
- GPIa
Alternate Names:
CD49b
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
- Immunocytochemistry
- Immunohistochemistry
- Affects Function
Entrez Gene Summary:
This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
UniProt Summary:
FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
SIZE: 1181 amino acids; 129295 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
SIZE: 1181 amino acids; 129295 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
Brand Family:
Chemicon
Product Name:
Anti-Integrin α2, clone P1E6
Concentration:
1 mg/mL
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μg
Format:
Purified
Host:
Mouse